Synthesis, Micellization and Hemolysis Evaluation of Biodegradable quaternary Ammonium Compounds

Surfactants have the special ability to interact with the lipid bilayer of cell membranes. The red blood cell is one of the most used cellular membrane models to study the mechanisms underlying surfactant – induced osmotic cell resistance.The aim of this study is the evaluation of the effect of the prepared surfactants on red blood cells (RBC) as a model for biological membranes. Also, in this study some of physicochemical and biodegradability properties were evaluated and studied. Series of cationic surfactants were prepared by the reaction of N,N dimethyl Tris(hydroxyl methyl) amino methane with fatty alkyl chlorides (C10–C18). We found a good correlation between the CMC and the concentrations resulting in maximum protection against hypotonic hemolysis for the cationic surfactants. The structures of the prepared compounds were confirmed by micro-analysis, IR and HNMR spectra.